Posts by George Henderson

  • Hard News: More on the repurposed…,

    Great news Russell,

    It's interesting that dexamethasone works, because...

    Dexamethasone Enhances 1α,25-Dihydroxyvitamin D3 Effects by Increasing Vitamin D Receptor Transcription.

    And people have been talking about vitamin D for a long time, strong evidence it affects survival but no big push to get deficient populations supplemented, despite death rates correlating with both vitamin D levels and skin tone, the best-known factor affecting vitamin D levels.

    Now that Fauci's on it, we'll see something happen quickly, but oh-oh - "The Iranian Drug..." I can hear that already.

    Auckland • Since Apr 2020 • 3 posts Report

  • Hard News: Has Iran found an effective…, in reply to Sacha,

    Elderberry has some ability to bind ACE2 and another coronavirus site. It looks good so far, is effective for flu of course, but like most of these things only studied in small trials with self-reported outcomes.
    The best evidence I've found is for probiotics, it takes a few months but they can double or triple flu vaccine seroprotection rates in healthy elderly people, and probably reduce the incidence of seasonal colds and flus.

    Auckland • Since Apr 2020 • 3 posts Report

  • Hard News: Has Iran found an effective…,

    These drugs are very specific for HCV and don't disrupt host processes to any meaningful extent. But different drug combos are specific for genotype 1 and genotype 3.
    How could this work for a completely different virus?
    Hep C drugs need to reduce viral load to "undetectable" because stealth features of HCV interaction with immune system mean it is a persistent infection which immune cells have little chance of clearing.
    Drugs only need to reduce COVID-19 by a decent amount - the immune system is always working on it and can clear it eventually, the drug just needs to give meaningful help (enough so the immune system needn't over-react would be cool).
    I have other questions about pharmakokinetics - it's easy to get drugs into the liver, because that's where they're detoxified, but the lungs?

    Note that rational drug design software has twice pinpointed the herbal andrographis panniculata, a traditional treatment for viral infections and cough.

    Auckland • Since Apr 2020 • 3 posts Report