Public Address | Cafe | Hard News: More on the repurposed hepatitis C drugs and their potential as a Covid-19 treatment https://publicaddress.net/system/cafe/ en-us Copyright (c) 2026 Public Address Thomas Lumley https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383991#post383991 https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383991#post383991 weird that the lab research finds it's daclatasvir that is the effective component and not sofosbuvir. Sofosbuvir is a nucleotide analogue, so you could easily imagine it inhibiting the RNA polymerase in other viruses the same way it does in HCV, but dataclatasvir binds in a… ]]> Thu, 20 Aug 2020 13:03:15 +1200 linger https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383990#post383990 https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383990#post383990 I know, right? I reported it as such 2 weeks ago. And again a week ago when it still hadn’t been removed from the multiple threads it inhabits. As I noted, persistent drug ads are an especially bad look for the threads on marijuana decriminalisation.
Hopefully the neglect means that…

]]> Sat, 15 Aug 2020 22:11:25 +1200 Worik Stanton https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383989#post383989 https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383989#post383989 Sat, 15 Aug 2020 10:26:47 +1200 George Henderson https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383968#post383968 https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383968#post383968 Great news Russell,

It's interesting that dexamethasone works, because...

Dexamethasone Enhances 1α,25-Dihydroxyvitamin D3 Effects by Increasing Vitamin D Receptor Transcription.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196110/

And people have been talking about vitamin D for a long time, strong evidence it affects survival but no big push to get deficient populations supplemented, despite death rates…

]]> Fri, 10 Jul 2020 16:56:16 +1200 Russell Brown https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383967#post383967 https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383967#post383967 That doesn’t seem credible to me. Looking at the preprint, we could do equivalent in vitro work here in NZ, so I’m be very surprised that there was no capacity to do the same in the whole of the US science system.

Yes, that is puzzling. More specifically, Victor Zonana,…

]]> Fri, 10 Jul 2020 11:06:39 +1200 Shaun Lott https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383966#post383966 https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383966#post383966 This whole avenue of work is super interesting and certainly shows some promise. I'm confused by

...efforts to have their work replicated in the US were stymied because all necessary resources were committed to vaccine development.

That doesn't seem credible to me. Looking at the preprint, we could do equivalent…

]]> Fri, 10 Jul 2020 10:37:26 +1200 Russell Brown https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383965#post383965 https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383965#post383965 the release on the trial data being presented to the Covid-19 conference. ]]> Fri, 10 Jul 2020 10:28:15 +1200 Public Address https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383964#post383964 https://publicaddress.net/system/cafe/hard-news-more-on-the-repurposed-hepatitis/?p=383964#post383964 Discussion from blog post.

]]> Fri, 10 Jul 2020 10:28:15 +1200