Hard News by Russell Brown

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Hard News: Has Iran found an effective Covid-19 treatment?

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  • Russell Brown,

    Kia ora!

    I have an update. There has been quite a bit happening around this, and the first publication, a pre-print, has landed a preclinical study from Brazil:

    To rapidly respond to an unfolded pandemics, it is pivotal to catalogue preclinical data on the susceptibility of SARS-CoV-2 to clinically approved drugs, as an attempt to trigger clinical trials with promising products (4). We used this approach during ZIKV, YFV, and CHIKV outbreak in Brazil, when we showed the susceptibility of these viruses to SFV (15– 18, 32). SFV and dacaltasvir are considered safe anti-HCV therapy with potential to be used with broader antiviral activity. Here, we demonstrated that SARS-CoV-2 is susceptible to daclatasvir, across different cell types tested, and to SFV, in a cell-dependent manner. In line with their activity against HCV, these drugs impaired SARS-CoV-2 RNA synthesis.

    There are also clinical trials in progress, and it seems that the original data from Iran is to be published in a peer-reviewed journal article. So more news is forthcoming.

    Auckland • Since Nov 2006 • 22849 posts Report Reply

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